{"id":428,"date":"2021-03-12T13:34:00","date_gmt":"2021-03-12T13:34:00","guid":{"rendered":"https:\/\/dev.gseo.dev\/sedpharma\/bfs-blow-fill-seal-sterile-from-start-to-finish\/"},"modified":"2022-11-10T17:51:01","modified_gmt":"2022-11-10T17:51:01","slug":"bfs-blow-fill-seal-sterile-from-start-to-finish","status":"publish","type":"post","link":"https:\/\/dev.gseo.dev\/sedpharma\/news-events\/bfs-blow-fill-seal-sterile-from-start-to-finish\/","title":{"rendered":"BFS (Blow Fill Seal): Sterile from Start to Finish"},"content":{"rendered":"<p><strong><em>BFS (Blow Fill Seal) technology<\/em><\/strong>\u00a0originated in Germany and has been widely used in the 1960s. At first it was mainly used in products such as rinses. In the 1970s, it was used in small-volume injections (such as eye drops packaging) and in the 1980s. For large-volume injections (such as infusion bottles). <a href=\"https:\/\/dev.gseo.dev\/sedpharma\/product\/bfs-aseptic-blow-fill-seal-machine-for-plastic-eye-drop-bottles\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-size: 18px; color: #548dd4; text-decoration: underline;\"><strong><em>BFS equipment<\/em><\/strong><\/span><\/a>\u00a0is\u00a0now\u00a0widely used in the fields of plastic packaging terminal sterilization products, aseptic products, etc., and is suitable for mass, uninterrupted production of products.<\/p>\n<p style=\"text-align: center;\">\u00a0<img decoding=\"async\" title=\"Asepetic Blow Fill Seal Machine.jpg\" src=\"https:\/\/dev.gseo.dev\/sedpharma\/wp-content\/uploads\/2022\/07\/3e97dd5909e9f4649f3db8ca3d7321b0.jpg\" alt=\"Asepetic Blow Fill Seal Machine.jpg\" \/><\/p>\n<p>BFS process starts by extruding a sterile polymer tube directly into the system. The container is then immediately formed, filled, sealed and demolded. Integrated operation, closed system, without external intervention. The delicate logistics of prefabricated containers and the time-consuming cleaning and sterilization process are no longer required.<\/p>\n<p>The entire filling path including the batching system is specially designed for CIP\/SIP. This means that all product transportation lines are cleaned through an automated procedure, sterilized with compressed steam and dried with sterile filtered air. This makes BFS technology the safest aseptic filling method.<\/p>\n<h2><span style=\"font-size: 18px;\"><strong><em>Process of Aseptic Blow-Fill-Seal Technology<\/em><\/strong><\/span><\/h2>\n<ul class=\" list-paddingleft-2\" style=\"list-style-type: disc;\">\n<li>\n<h3><span style=\"font-size: 16px;\"><strong><em>Extrusion<\/em><\/strong><\/span><\/h3>\n<\/li>\n<\/ul>\n<p>The plastic tube extruded from the granules is fed into the opened blow mold<\/p>\n<ul class=\" list-paddingleft-2\" style=\"list-style-type: disc;\">\n<li>\n<h3><span style=\"font-size: 16px;\"><strong><em>Forming<\/em><\/strong><\/span><\/h3>\n<\/li>\n<\/ul>\n<p>The main mold is closed to seal the bottom of the container. The mandrel enters the neck of the mold, and compressed air is used to blow the tube blank into shape. Smaller containers are vacuum formed.<\/p>\n<p style=\"text-align: center;\"><img decoding=\"async\" title=\"Process of BFS.jpg\" src=\"https:\/\/dev.gseo.dev\/sedpharma\/wp-content\/uploads\/2022\/07\/6269cb0dd4765753ac1af08d01df10a9.jpg\" alt=\"Process of BFS.jpg\" \/><\/p>\n<ul class=\" list-paddingleft-2\" style=\"list-style-type: disc;\">\n<li>\n<h3><span style=\"font-size: 16px;\"><strong><em>Filling<\/em><\/strong><\/span><\/h3>\n<\/li>\n<\/ul>\n<p>The liquid medicine is filled into the container through the mandrel under the precise control of the filling system.<\/p>\n<ul class=\" list-paddingleft-2\" style=\"list-style-type: disc;\">\n<li>\n<h3><strong><em><span style=\"font-size: 16px;\">Sealing<\/span><\/em><\/strong><\/h3>\n<\/li>\n<\/ul>\n<p>The mandrel is removed, the head mold is closed, and the designed sealing part is vacuum formed.<\/p>\n<ul class=\" list-paddingleft-2\" style=\"list-style-type: disc;\">\n<li>\n<h3><strong><em><span style=\"font-size: 16px;\">Demold<\/span><\/em><\/strong><\/h3>\n<\/li>\n<\/ul>\n<p>Open the\u00a0mold,\u00a0the container leaves the mold, and the next cycle begins. The conveyor belt takes the container to the next process.<\/p>\n<h2><span style=\"font-size: 18px;\"><strong><em>Application of Blow Fill Seal Equipment<\/em><\/strong><\/span><\/h2>\n<p>Whether it is to fill a bottle or an ampoule, what to fill, how to fill it, and what function the container needs are usually based on the end uasge. The BFS equipment\u00a0can use different plastics to automatically produce different containers such as cans, tubes, ampoules, dropper bottles, pouch bottles and single-dose packaging. The filling volume ranges from 0.04 to 10,000 ml.<\/p>\n<p><strong><em>BFS technology<\/em><\/strong> can be used for aseptic packaging\u00a0of ophthalmic products, respiratory (inhalation) drugs, biological preparations, vaccines and other injection drugs, enabling continuous, automatic molding, filling and sealing of unit-dose liquid packaging.<\/p>\n<p>Avaliable packaging containers\u00a0include ampoules, vials and bottles, and the sterility of the product can be guaranteed during the entire process. Compared with glass packaging, the benefits of BFS include reducing waste and breakage, and eliminating product preservatives that may be allergic to patients.<\/p>\n<p style=\"text-align: center;\">\u00a0<img decoding=\"async\" title=\"BFS finished products.jpg\" src=\"https:\/\/dev.gseo.dev\/sedpharma\/wp-content\/uploads\/2022\/07\/37a4edbe2c441e8ca7539fc4772d5f6e.jpg\" alt=\"BFS finished products.jpg\" \/><\/p>\n<p>The <strong><em>bfs aseptic filling<\/em><\/strong>\u00a0is more flexible and more economical than the traditional filling process. But BFS technology is not only used as the preferred technology in the pharmaceutical field. But also more and more widely used in the chemical and food\u00a0industries.<\/p>\n<h2><span style=\"font-size: 18px;\"><strong><em>Technical Advantages\u00a0of BFS<\/em><\/strong><\/span><\/h2>\n<ul class=\" list-paddingleft-2\" style=\"list-style-type: disc;\">\n<li>Fully enclosed to effectively isolate particles: It has a closed system that is isolated from the outside world, and the liquid medicine transmission system, filtration system, and filling system are fully enclosed, which can effectively control and isolate particles.<\/li>\n<li>Integrated and more efficient: Blow molding, filling, and sealing are completed in the same station of the same equipment, forming in one step, and the whole process takes only 11 seconds.<\/li>\n<li>High performance, sterile and dust-free: automatic online cleaning\/sterilization, the system maintains a positive pressure, which can achieve sterile effects.<\/li>\n<\/ul>\n<h2><span style=\"font-size: 18px;\"><strong><em>How to Identify BFS packaging?<\/em><\/strong><\/span><\/h2>\n<p><strong><em>BFS technology<\/em><\/strong>\u00a0has a more obvious way of identification:<\/p>\n<p>\u2460\u00a0The bottle is integrally formed without a combined cap<\/p>\n<p>\u2461\u00a0There will be an integrated molding suture at the mouth of the bottle<\/p>\n<p>\u2462\u00a0For smaller dosage forms: For example, 10mL, 5 bottles are formed in a row. The packaging is divided between the bottles, and the suture lines between the rows of bottles can be seen in a single bottle.<\/p>\n<p>Find more <a href=\"https:\/\/dev.gseo.dev\/sedpharma\/product-category\/dosage-processing-equipment\/eye-drop-dosage-equipment\/\" target=\"_blank\" rel=\"noopener\"><span style=\"color: #548dd4; text-decoration: underline; font-size: 18px;\"><strong><em>eye drop dosage equipment<\/em><\/strong><\/span><\/a> such as eye drop bottle rinser, eye drop filling and capping machine on our website!<\/p>\n","protected":false},"excerpt":{"rendered":"<p>BFS (Blow Fill Seal) technology\u00a0originated in Germany and has been widely used in the 1960s. At first it was mainly used in products such as rinses. In the 1970s, it was used in small-volume injections (such as eye drops packaging) and in the 1980s. For large-volume injections (such as infusion bottles). BFS equipment\u00a0is\u00a0now\u00a0widely used in [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":429,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[50],"tags":[],"class_list":["post-428","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-case-study"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v19.10 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>BFS (Blow Fill Seal): Sterile from Start to Finish - SED Pharma<\/title>\n<meta name=\"description\" content=\"Blow Fill Seal originated in Germany and has been used since the 1960s. 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